ChemInform Abstract: Synthesis of Urea Tethered Glycosylated Amino Acids and Glycopeptides Mediated by DPPA Employing Nα-Fmoc-Asp/Glu-5-oxazolidinones.
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ChemInform Abstract: Direct Synthesis of β- Hydroxy-α-amino Acids via Diastereoselective Decarboxylative Aldol..
A straightforward metal-free synthesis of anti-β-hydroxy-r-amino acids is described. The organic base-mediated decarboxylative aldol reaction of cheap, readily available r-amidohemimalonates with various aldehydes afforded under very mild conditions anti-β-hydroxy-r-amido esters in high yields and complete diastereoselectivity. Simple one-pot subsequent transformations enabled the corresponding...
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A review of the chemical structure, pharmacokinetics, spectrum of activity, clinical use, and adverse effects of oxazolidinones (linezolid), glycopeptides, and cyclic lipopeptides (daptomycin) is presented. Oxazolidinones inhibit protein synthesis, and glycopeptides and cyclic lipopeptides act against the bacterial cell wall. The antibacterial spectrum of these agents covers gram-positive patho...
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[reaction: see text] 5'-Peptide oligonucleotide conjugates were prepared stepwise on a single support using N(alpha)-Fmoc-protected amino acids and unprotected phosphate groups. The method uses commercially available reagents and is successful with most natural amino acids. The simplicity of the method may encourage researchers to prepare new oligonucleotide-peptide conjugates with novel proper...
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Background The catalysis of reactions with organic molecules void of transition metals has lately assumed a prominent role in asymmetric synthesis. Among different catalysts, proline, an abundant, inexpensive amino acid available in both enantiomeric forms, has emerged as arguably the most practical and versatile. The simultaneous presence of a carboxylic acid and amine bestows a unique bifunct...
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Synthesis and characterization of two functionalized gold nanoparticles by using of two poly functional amino acids (L-Arginine and L-Aspartic acid) are reported. The gold nanoparticles were reduced by sodium citrate and functionalized with L-Arginine at the pH of 7 and 11 and L-Aspartic acid at the pH of 7. Transmission electron microscopy, UV-Vis spectroscopy, dynamic light scattering, zeta p...
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ژورنال
عنوان ژورنال: ChemInform
سال: 2009
ISSN: 0931-7597,1522-2667
DOI: 10.1002/chin.200928174